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« "Pakistanis Kill 80 in Raid on [Terror] School" | Main | I've Joined the Army » October 31, 2006
Hold the Donut
Posted by Bill Reynolds has a good round-up on some of the latest news in anti-aging technology, initially focusing on caloric restriction and compounds that mimic the effects of caloric restriction, notably resveratrol, which is found in red wine. Being a proponent of the "have cake and eat it to" school of thought, the good professor downplays the utility of caloric restriction: That's absolutely right. Calorie restriction is unlikely to work in humans -- and I'm not sure it's worth it anyway -- but drugs that mimic its effects are another thing entirely. By "unlikely to work," he means "will not drastically extend lifespan." And he's correct: To emulate the mice experiments, calorie restriction of humans would need to start around 2 or 3 years of age and provide all necessary nutrients. A fully-grown human adult raised on a 40% calorie restricted diet would weigh 75 pounds instead the normal 150 pounds. Presumably such humans could live to an age of 120 years under ideal conditions ... That said, there's every indication that caloric restriction (both moderate and severe) can help slow and prevent degenerative processes and maintain quality of life to a point just before one kicks: Technology Review: What's the most striking finding you've seen in those following a calorie-restricted diet so far? Besides the celebrated increase in longevity, tests subjects in caloric restriction experiments display marked vitality until death. So it's not a bad strategy to stave off deterioration, especially in moderate incarnations that focus on maintaining low blood sugar levels and ideal weight: Scientists from the University of Florida's Institute on Aging have found that eating a little less food and exercising a little more over a lifespan can reduce or even reverse aging-related cell and organ damage in rats. A good sumation of caloric restriction is here. Regarding the potential of a "resveratrol pill" that tricks the body into thinking that it's hungry, I have concerns/curiosity about what this does to energy storage and utilization when one is actually exercising and eating a normal or heavy diet. If the anti-aging effects are a result of reduced cell metabolism (mitochondrial energy production, waste creation and disposal), what does it mean to require the cells to process normal diet and activity while tricking them into thinking they don't have to? I suppose we'll find out. Posted by Bill at October 31, 2006 09:18 AM | TrackBack (3) Trackback PingsTrackBack URL for this entry: CommentsAnd how much longer do you think that 120 years would feel considering the impaired mental funtion. Posted by: aaron at October 31, 2006 03:55 PM A fully-grown human adult raised on a 40% calorie restricted diet would weigh 75 pounds instead the normal 150 pounds. Not to mention getting your butt kicked three times a day by 10 year olds. 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