INDC Journal

« "Pakistanis Kill 80 in Raid on [Terror] School" | Main | I've Joined the Army »

October 31, 2006
Hold the Donut

Posted by Bill

Reynolds has a good round-up on some of the latest news in anti-aging technology, initially focusing on caloric restriction and compounds that mimic the effects of caloric restriction, notably resveratrol, which is found in red wine. Being a proponent of the "have cake and eat it to" school of thought, the good professor downplays the utility of caloric restriction:

That's absolutely right. Calorie restriction is unlikely to work in humans -- and I'm not sure it's worth it anyway -- but drugs that mimic its effects are another thing entirely.

By "unlikely to work," he means "will not drastically extend lifespan." And he's correct:

To emulate the mice experiments, calorie restriction of humans would need to start around 2 or 3 years of age and provide all necessary nutrients. A fully-grown human adult raised on a 40% calorie restricted diet would weigh 75 pounds instead the normal 150 pounds. Presumably such humans could live to an age of 120 years under ideal conditions ...

That said, there's every indication that caloric restriction (both moderate and severe) can help slow and prevent degenerative processes and maintain quality of life to a point just before one kicks:

Technology Review: What's the most striking finding you've seen in those following a calorie-restricted diet so far?

John Holloszy: They are powerfully protected against the diseases of old age, such as heart disease. They have low levels of cholesterol and triglycerides and extremely low blood pressure -- similar to a young child, around 100/60. As a result of the low blood pressure, they have less strain on the arteries, which are much more elastic than usual for people of their age. Their hearts resemble the heart of a person 17 years younger. They also have very good insulin sensitivity, so they are not going to get Type 2 diabetes.

Besides the celebrated increase in longevity, tests subjects in caloric restriction experiments display marked vitality until death. So it's not a bad strategy to stave off deterioration, especially in moderate incarnations that focus on maintaining low blood sugar levels and ideal weight:

Scientists from the University of Florida's Institute on Aging have found that eating a little less food and exercising a little more over a lifespan can reduce or even reverse aging-related cell and organ damage in rats.

The discovery, described this month in the journal Antioxidants and Redox Signaling, builds on recent research in animals and humans that has shown a more drastic 20 percent to 40 percent cut in calories slows aging damage. The UF findings indicate even small reductions in calories could have big effects on health and shed light on the molecular process responsible for the phenomenon, which until now has been poorly understood.

A good sumation of caloric restriction is here.

Regarding the potential of a "resveratrol pill" that tricks the body into thinking that it's hungry, I have concerns/curiosity about what this does to energy storage and utilization when one is actually exercising and eating a normal or heavy diet. If the anti-aging effects are a result of reduced cell metabolism (mitochondrial energy production, waste creation and disposal), what does it mean to require the cells to process normal diet and activity while tricking them into thinking they don't have to? I suppose we'll find out.

Posted by Bill at October 31, 2006 09:18 AM | TrackBack (3)

Trackback Pings

TrackBack URL for this entry:
http://www.indcjournal.com/cgi-bin/mt/dafrules/tapaz.cgi/2796

Comments

And how much longer do you think that 120 years would feel considering the impaired mental funtion.

Posted by: aaron at October 31, 2006 03:55 PM

A fully-grown human adult raised on a 40% calorie restricted diet would weigh 75 pounds instead the normal 150 pounds.

Not to mention getting your butt kicked three times a day by 10 year olds.

Posted by: Veeshir at November 1, 2006 08:19 AM

lipitor diabetes lipitor diabetes

Posted by: lipitor diabetes at November 17, 2006 07:20 PM

See busty girls

Posted by: big tit at November 17, 2006 07:28 PM

Hello, her first big cock here!

Posted by: big cock at November 18, 2006 01:26 AM

oh look on that cool milf womans inside

Posted by: milf seeker at November 18, 2006 07:16 AM

Noi ti forniamo una facile e versatile visione d'insieme del tuo portafoglio - questo rende piú facile seguire il tuo rendimento.

Posted by: Milf Crusier at November 18, 2006 11:55 PM

Twistys Presents: Kyla Cole

Posted by: kyla cole at November 19, 2006 01:53 AM

All about ass traffic

Posted by: ass traffic at November 19, 2006 10:01 AM

Twistys Presents: Veronica Zemanova

Posted by: veronica zemanova at November 19, 2006 07:10 PM

Twistys Presents: Peach

Posted by: peach at November 21, 2006 08:23 AM

Twistys Presents: Zdenka

Posted by: zdenka at November 21, 2006 02:21 PM

Twistys Presents: Jana Cova

Posted by: jana cova at November 22, 2006 02:07 AM

Twistys Presents: Eva Shine

Posted by: eva shine at November 22, 2006 04:12 AM

Twistys Presents: Erica Campbell

Posted by: erica campbell at November 22, 2006 06:19 AM

I haven't been up to much lately. So it goes. What can I say? I've just been letting everything wash over me recently, not that it matters. I just don't have much to say these days.
I haven't been up to much lately. So it goes. What can I say? I've just been letting everything wash over me recently, not that it matters. I just don't have much to say these days.
More or less nothing seems important. It's not important. Shrug. Whatever. I've just been hanging out doing nothing, but eh. I can't be bothered with anything lately.

Posted by: need dental insurance at December 11, 2006 10:17 PM

Innocent cute babe gives blowjob & gets facial

Posted by: blowjob at December 19, 2006 10:25 AM

Sexy Brunette Bitch In Bikini Giving Handjob

Posted by: handjob at December 19, 2006 04:21 PM

Busty Teen Interracial Gets Fucked In Tight Ass

Posted by: interracial at December 19, 2006 10:25 PM

Busty Blonde Licking Boobs & Shows Nipples

Posted by: Breasts at December 20, 2006 06:52 AM

Hot Babe Double Penetration Ass-to-mouth Hardcore

Posted by: Double Penetration at December 20, 2006 12:28 PM

Blond Babe With Big Tits Sucking & Titty Cumshot

Posted by: Cumshot at December 20, 2006 06:58 PM

Sporty Tanned Blond MILF Shows Shaved Upskirt Cunt

Posted by: milf at December 21, 2006 12:26 PM

Slutty Teen Sucking Black Monster Cock & Cumshot

Posted by: monsters cock at December 22, 2006 12:45 AM

Blond Slut Anal Fucked By Monster Cock

Posted by: big cock at December 22, 2006 07:18 AM

Hot Babe Tied Up Clamped Cunt & Huge Dildo Assfuck

Posted by: ass at December 22, 2006 01:19 PM

Pornstar Jasmine Bryne Assfucked & Swallowing Cum

Posted by: ass parade at December 22, 2006 07:47 PM

Brunette With Huge Boobs Titty Fucking & Posing

Posted by: big tits at December 23, 2006 01:48 AM

Curly Haired Brunette Tittyfucking With Big Tits

Posted by: big tits round asses at December 23, 2006 08:00 AM

Busty Babe Shows Huge Tits & Fingered Cunt

Posted by: busty at December 23, 2006 02:08 PM

Nude Busty Tanned Blondes Fucked In Bedroom Orgy

Posted by: busty adventures at December 23, 2006 08:14 PM

Sexy Blond MILF Garterbelts Hardcore Fucked

Posted by: bang milf at December 24, 2006 02:30 PM

Tight Busty Tanned Blond MILF Showing Shaved Pussy

Posted by: amateur milf at December 24, 2006 08:48 PM

Busty MILF Gets Hardcore Doggystyle Bang On Bed

Posted by: best milf at December 25, 2006 03:01 AM

Hot Tight MILF Getting Fucked In The Car

Posted by: bikini milf at December 25, 2006 03:30 PM

Chubby MILF With Big Natural Tits & Tattoo Banging

Posted by: black milf at December 25, 2006 09:44 PM

Classy Chick Sucking Monster Cock Action

Posted by: monsters cock at December 26, 2006 10:50 AM

Teen Sucks Monster Cock Wants To Swallow Cumshot

Posted by: big cock action at December 27, 2006 12:01 AM

Cute Petite Lesbians Suck Monster Cock In Garage

Posted by: monsters of cock at December 27, 2006 12:51 PM

Blond Lesbians Fucked By Doctor With Monster Cocks

Posted by: xxx cock at December 27, 2006 07:07 PM

Tanned Hairless Blonde Fucks Monster Cock For Cum

Posted by: ass cock at December 28, 2006 01:45 AM

Pornstar Vega Vixen Muffdiving & Assfucked FFM

Posted by: big ass at December 28, 2006 08:19 AM

Shaved Blond Latina In Fishnet Stockings Assfucked

Posted by: black ass at December 28, 2006 10:02 PM

Topless Tanned Shemale Fucked Oral & Assfucking

Posted by: nice ass at December 29, 2006 04:55 AM

Tall Shemale With Tan Lines Assfucking Doggystyle

Posted by: ass hole at December 29, 2006 11:36 AM

Blond Girl Anal Toyinh & Ass Fucked Hardcore

Posted by: ass fucking at December 29, 2006 06:05 PM

Ebony Girl Assfucking & Fucking 69 In FFM 3some

Posted by: fat ass at December 30, 2006 12:45 AM

Mature Woman With Glasses Titfucking

Posted by: big black tit at December 30, 2006 09:55 PM

Blonde Tittyfucking & Spreads Pussy On Sofa

Posted by: big natural tit at December 31, 2006 04:58 AM

Busty Tanned Blond Mom Titty Fucking Interracial

Posted by: big tit teen at December 31, 2006 11:53 AM

Busty Beauty Gives Big Titty Fuck & Snatch Banging

Posted by: big tit movie at December 31, 2006 06:27 PM

Busty Blond Sorority Girl Tittyfuck & Riding Cock

Posted by: mature big tit at January 1, 2007 02:26 PM

Hairless Busty Exotic Bimbo Fucking Dildo Outdoor

Posted by: busty teen at January 1, 2007 09:08 PM

Busty Tanned Babes Fucked On Sofa 3some

Posted by: busty babes at January 2, 2007 04:04 AM

Busty Blond Bombshell Big Tits Screws Dildo Nude

Posted by: busty adventure at January 2, 2007 10:51 AM

Busty Babe Gets Pussy Licked In Garage Hardcore

Posted by: busty asian at January 2, 2007 05:36 PM

Busty Beauty Titties Clamped & Hogtied

Posted by: busty blonde at January 3, 2007 12:26 AM

Busty Fetish Blond Mistress Torturing Slave Femdom

Posted by: busty mature at January 3, 2007 07:09 AM

Busty Dark Haired Babe Shows Hairy Pussy

Posted by: busty girl at January 3, 2007 01:56 PM

I grandi vecchi delle dittature mondiali si spengono. Fidel è grave e ieri è morto Pinochet, ironia della sorte nella
I can't be bothered with anything lately. My mind is like a fog. I've just been hanging out not getting anything done. I've more or less been doing nothing.
I've just been letting everything pass me by , but so it goes. I just don't have much to say these days. Pfft. I can't be bothered with anything. More or less nothing seems worth doing. I haven't gotten much done recently, but oh well.

Posted by: cock sucker at January 5, 2007 02:02 PM

Quer aprender ASP?! Veja este material gratuito
O governo estuda a proposta de criacao da idade minima de 67 anos para homens e mulheres se aposentarem pelo INSS
My life's been pretty dull these days. Not much on my mind recently. My mind is like a fog, but shrug. I haven't been up to anything today, but oh well. I haven't gotten much done lately.

Posted by: busty adventures at January 5, 2007 09:01 PM

My life's been pretty dull lately, but I guess it doesn't bother me. I haven't been up to anything recently. Maybe tomorrow. I've pretty much been doing nothing worth mentioning. I haven't gotten much done these days. Pretty much nothing seems worth thinking about.

Posted by: nude at January 6, 2007 11:50 AM

I feel like a fog, not that it matters. I've pretty much been doing nothing , but eh. Today was a loss. I haven't gotten much done for a while.

Posted by: tug jobs at January 9, 2007 04:50 AM

I can't be bothered with anything recently. I've just been sitting around doing nothing. Today was a loss. I just don't have much to say. Nothing seems worth thinking about.

Posted by: bang bros at January 9, 2007 08:33 PM

I've pretty much been doing nothing worth mentioning. I haven't gotten anything done today. I haven't been up to much , but oh well. I've just been staying at home waiting for something to happen, but so it goes. Pfft.

Posted by: public invasion at January 10, 2007 09:14 AM

I've just been staying at home waiting for something to happen. I've just been letting everything wash over me. I can't be bothered with anything recently.

Posted by: bait bus at January 10, 2007 03:38 PM

Nothing notable going on. My life's been generally dull today. So it goes. Not much on my mind to speak of.

Posted by: bang bros at January 10, 2007 10:23 PM

I haven't gotten anything done today. My life's been dull today, but shrug. I can't be bothered with anything recently, but oh well. I've just been sitting around doing nothing. What can I say? So it goes.

Posted by: taylor bow at January 11, 2007 06:09 PM

I haven't gotten anything done. Whatever. I just don't have anything to say.

Posted by: ball honeys at January 12, 2007 12:46 AM

L’interet du forum est precisement de susciter un debat parmi les citoyens pour que le budget et les choix qu’il sous-tend soient places au c?ur du debat public. Un budget, ce sont des choix. Des choix supposent des priorites.

Posted by: big ass at January 12, 2007 07:45 AM

O governo estuda a proposta de criacao da idade minima de 67 anos para homens e mulheres se aposentarem pelo INSS

Posted by: summer milf at January 12, 2007 09:11 PM

meu site... queria que avaliassem e dessem opinioes!

Posted by: street ranger at January 13, 2007 07:41 AM

We are killing the rainforest

Posted by: nude girls at January 31, 2007 10:19 AM

I haven't been up to much these days. Such is life. I've just been letting everything happen without me these days, but I don't care.

Posted by: nude girls at January 31, 2007 10:23 AM

Pot should be, should not be decriminalized

Posted by: 15on1 jennifer at February 1, 2007 09:00 AM

Needle exchange programs help to prevent

Posted by: 15on1 jennifer at February 1, 2007 09:04 AM

It is never okay to lie, sometimes okay to lie

Posted by: flexible girls at February 1, 2007 11:34 AM

Peace in the Middle East is obtainable with US and The European Union intervention

Posted by: glamour girls at February 2, 2007 05:11 AM

Vegetarianism is bad, is not bad for your health

Posted by: glamour girls at February 2, 2007 05:12 AM

My life's been pretty dull lately, but I guess it doesn't bother me. I haven't been up to anything recently. Maybe tomorrow. I've pretty much been doing nothing worth mentioning. I haven't gotten much done these days. Pretty much nothing seems worth thinking about.

Posted by: Glamour Models at February 2, 2007 01:37 PM

Americans owe, doesn't owe Vietnam veterans an apology

Posted by: blow job petite teen at February 4, 2007 12:11 AM

People should be allowed to go naked in certain recreational areas only - Or specify those areas and you have another persuasive speech topic

Posted by: love bisexuals at February 5, 2007 09:52 AM